Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential in repairing DNA alkylation damage, under certain conditions, initiation o...

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Autors principals: Calvo, Jennifer A., Moroski-Erkul, Catherine A., Lake, Annabelle, Eichinger, Lindsey W., Shah, Dharini, Jhun, Iny, Limsirichai, Prajit, Bronson, Roderick T., Christiani, David C., Meira, Lisiane B., Samson, Leona D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617098/
https://ncbi.nlm.nih.gov/pubmed/23593019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003413
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