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PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration
Alkylating agents are commonly used to treat cancer. Although base excision repair (BER) is a major pathway for repairing DNA alkylation damage, under certain conditions, the initiation of BER produces toxic repair intermediates that damage healthy tissues. The initiation of BER by the alkyladenine...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5620290/ https://ncbi.nlm.nih.gov/pubmed/28978150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19844 |
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