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Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms

Alkylating agents are ubiquitous in our internal and external environments, causing DNA damage that contributes to mutations and cell death that can result in aging, tissue degeneration and cancer. Repair of methylated DNA bases occurs primarily through the base excision repair (BER) pathway, a mult...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Margulies, Carrie M., Chaim, Isaac Alexander, Mazumder, Aprotim, Criscione, June, Samson, Leona D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590993/
https://ncbi.nlm.nih.gov/pubmed/28886188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184619
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