Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms

Alkylating agents are ubiquitous in our internal and external environments, causing DNA damage that contributes to mutations and cell death that can result in aging, tissue degeneration and cancer. Repair of methylated DNA bases occurs primarily through the base excision repair (BER) pathway, a mult...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Margulies, Carrie M., Chaim, Isaac Alexander, Mazumder, Aprotim, Criscione, June, Samson, Leona D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590993/
https://ncbi.nlm.nih.gov/pubmed/28886188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184619
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