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Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1.
Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential in repairing DNA alkylation damage, under certain conditions, initiation o...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science (PLoS)
2013-04-01
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Colecção: | PLoS Genetics |
Acesso em linha: | http://europepmc.org/articles/PMC3617098?pdf=render |
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