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Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice

Vision loss affects >3 million Americans and many more people worldwide. Although predisposing genes have been identified their link to known environmental factors is unclear. In wild-type animals DNA alkylating agents induce photoreceptor apoptosis and severe retinal degeneration. Alkylation-ind...

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מידע ביבליוגרפי
Main Authors: Meira, Lisiane B., Moroski-Erkul, Catherine A., Green, Stephanie L., Calvo, Jennifer A., Bronson, Roderick T., Shah, Dharini, Samson, Leona D.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2009
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2621254/
https://ncbi.nlm.nih.gov/pubmed/19139400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807030106
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