Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential in repairing DNA alkylation damage, under certain conditions, initiation o...

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Autores principales: Calvo, Jennifer A., Moroski-Erkul, Catherine A., Lake, Annabelle, Eichinger, Lindsey W., Shah, Dharini, Jhun, Iny, Limsirichai, Prajit, Bronson, Roderick T., Christiani, David C., Meira, Lisiane B., Samson, Leona D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617098/
https://ncbi.nlm.nih.gov/pubmed/23593019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003413
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