Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential in repairing DNA alkylation damage, under certain conditions, initiation o...

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Detalhes bibliográficos
Main Authors: Calvo, Jennifer A., Moroski-Erkul, Catherine A., Lake, Annabelle, Eichinger, Lindsey W., Shah, Dharini, Jhun, Iny, Limsirichai, Prajit, Bronson, Roderick T., Christiani, David C., Meira, Lisiane B., Samson, Leona D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617098/
https://ncbi.nlm.nih.gov/pubmed/23593019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003413
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