Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering

Protease-activated receptor-2 (PAR(2)) is a G-protein coupled receptor (GPCR) associated with a variety of pathologies. However, the therapeutic potential of PAR(2) is limited by a lack of potent and specific ligands. Following proteolytic cleavage, PAR(2) is activated through a tethered ligand. Hen...

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Detalhes bibliográficos
Main Authors: Flynn, Andrea N., Hoffman, Justin, Tillu, Dipti V., Sherwood, Cara L., Zhang, Zhenyu, Patek, Renata, Asiedu, Marina N. K., Vagner, Josef, Price, Theodore J., Boitano, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606532/
https://ncbi.nlm.nih.gov/pubmed/23292071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-217323
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