The Protease-activated Receptor-2-specific Agonists 2-Aminothiazol-4-yl-LIGRL-NH(2) and 6-Aminonicotinyl-LIGRL-NH(2) Stimulate Multiple Signaling Pathways to Induce Physiological Responses in Vitro and in Vivo

Protease-activated receptor-2 (PAR(2)) is one of four protease-activated G-protein-coupled receptors. PAR(2) is expressed on multiple cell types where it contributes to cellular responses to endogenous and exogenous proteases. Proteolytic cleavage of PAR(2) reveals a tethered ligand that activates P...

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Detalhes bibliográficos
Main Authors: Flynn, Andrea N., Tillu, Dipti V., Asiedu, Marina N., Hoffman, Justin, Vagner, Josef, Price, Theodore J., Boitano, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099721/
https://ncbi.nlm.nih.gov/pubmed/21467041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.185264
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