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Lanthanide labeling of a potent protease activated receptor-2 agonist for time-resolved fluorescence analysis

Protease activated receptor-2 (PAR(2)) is one of four G-protein coupled receptors (GPCRs) that can be activated by exogenous or endogenous proteases, which cleave the extracellular amino-terminus to expose a tethered ligand and subsequent G-protein signaling. Alternatively, PAR(2) can be activated b...

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Detalhes bibliográficos
Main Authors: Hoffman, Justin, Flynn, Andrea N., Tillu, Dipti V., Zhang, Zhenyu, Patek, Renata, Price, Theodore J., Vagner, Josef, Boitano, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556274/
https://ncbi.nlm.nih.gov/pubmed/22994402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc300300q
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