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Development and Evaluation of Small Peptidomimetic Ligands to Protease-Activated Receptor-2 (PAR(2)) through the Use of Lipid Tethering
Protease-activated receptor-2 (PAR(2)) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL). We evaluated the ability for lipid-tethered-peptidomimetics to activate PAR(2) with in vitro physiological and Ca(2+) signaling assays to d...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4057235/ https://ncbi.nlm.nih.gov/pubmed/24927179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099140 |
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