Rapid activation of monocyte tissue factor by antithymocyte globulin is dependent on complement and protein disulfide isomerase

Lymphocyte depletion with antithymocyte globulin (ATG) can be complicated by systemic coagulation activation. We found that ATG activated tissue factor procoagulant activity (TF PCA) on monocytic cells more potently than other stimuli that decrypt TF, including cell disruption, TF pathway inhibitor...

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Autores principales: Langer, Florian, Spath, Brigitte, Fischer, Cornelia, Stolz, Moritz, Ayuk, Francis A., Kröger, Nicolaus, Bokemeyer, Carsten, Ruf, Wolfram
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2013
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606067/
https://ncbi.nlm.nih.gov/pubmed/23315166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-10-460493
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