The disulfide isomerase ERp72 supports arterial thrombosis in mice

Several CGHC motif–containing disulfide isomerases support thrombosis. We here report that endoplasmic reticulum protein 72 (ERp72), with 3 CGHC redox-active sites (a(o), a, and a′), supports thrombosis. We generated a new conditional knockout mouse model and found that Tie2-Cre/ERp72(fl/fl) mice wi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Zhou, Junsong, Wu, Yi, Chen, Fengwu, Wang, Lu, Rauova, Lubica, Hayes, Vincent M., Poncz, Mortimer, Li, Hong, Liu, Tong, Liu, Junling, Essex, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553574/
https://ncbi.nlm.nih.gov/pubmed/28576878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-12-755587
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