Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice

Protein disulfide isomerase (PDI) derived from intravascular cells is required for thrombus formation. However, it remains unclear whether platelet PDI contributes to the process. Using platelet-specific PDI–deficient mice, we demonstrate that PDI-null platelets have defects in aggregation and adeno...

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Detalhes bibliográficos
Main Authors: Kim, Kyungho, Hahm, Eunsil, Li, Jing, Holbrook, Lisa-Marie, Sasikumar, Parvathy, Stanley, Ronald G., Ushio-Fukai, Masuko, Gibbins, Jonathan M., Cho, Jaehyung
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739031/
https://ncbi.nlm.nih.gov/pubmed/23788140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-492504
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