Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice

Protein disulfide isomerase (PDI) derived from intravascular cells is required for thrombus formation. However, it remains unclear whether platelet PDI contributes to the process. Using platelet-specific PDI–deficient mice, we demonstrate that PDI-null platelets have defects in aggregation and adeno...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kim, Kyungho, Hahm, Eunsil, Li, Jing, Holbrook, Lisa-Marie, Sasikumar, Parvathy, Stanley, Ronald G., Ushio-Fukai, Masuko, Gibbins, Jonathan M., Cho, Jaehyung
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2013
Pynciau:
Thrombosis and Hemostasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739031/
https://ncbi.nlm.nih.gov/pubmed/23788140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-492504
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