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Temporal and spatial characterization of nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism responsible for “surveying” mRNAs during translation and degrading those that harbor a premature termination codon (PTC). Currently the intracellular spatial location of NMD and the kinetics of its decay step in mammalian cells are un...

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Bibliografske podrobnosti
Main Authors: Trcek, Tatjana, Sato, Hanae, Singer, Robert H., Maquat, Lynne E.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605467/
https://ncbi.nlm.nih.gov/pubmed/23431032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.209635.112
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