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Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay

Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical effector of cellular phenotype, i.e., proteins, tight regulation of both the quality and quantity of mRNA is a prerequisite for eff...

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Main Authors: Popp, Maximilian Wei-Lin, Maquat, Lynne E.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148824/
https://ncbi.nlm.nih.gov/pubmed/24274751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-genet-111212-133424
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