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Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics
Nonsense-mediated mRNA decay (NMD) limits the production of aberrant mRNAs containing a premature termination codon and also controls the levels of endogenous transcripts. Here we show that when human cells are treated with clinically used chemotherapeutic compounds, NMD activity declines partly as...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375787/ https://ncbi.nlm.nih.gov/pubmed/25808464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7632 |
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