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Nonsense-mediated mRNA decay in humans at a glance

Nonsense-mediated mRNA decay (NMD) is an mRNA quality-control mechanism that typifies all eukaryotes examined to date. NMD surveys newly synthesized mRNAs and degrades those that harbor a premature termination codon (PTC), thereby preventing the production of truncated proteins that could result in...

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Bibliografske podrobnosti
izdano v:J Cell Sci
Main Authors: Kurosaki, Tatsuaki, Maquat, Lynne E.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760306/
https://ncbi.nlm.nih.gov/pubmed/26787741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.181008
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