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Quality and quantity control of gene expression by nonsense-mediated mRNA decay
Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most evolutionarily conserved cellular quality control mechanisms. Although NMD was first found to target one-third of mutated, disease-causing mRNAs, it is now known to also target ~10% of unmutated mammalian mRNAs to facilitat...
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| Publicado no: | Nat Rev Mol Cell Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6855384/ https://ncbi.nlm.nih.gov/pubmed/30992545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41580-019-0126-2 |
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