Synthesis and biological activity of 5-chloro-N(4)-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents(1)

Inhibition of receptor tyrosine kinase (RTK) signaling pathways is an important area for the development of novel anticancer agents. Numerous multikinase inhibitors (MKIs) have been recently approved for the treatment of cancer. Vascular endothelial growth factor receptor-2 (VEGFR-2) is the principa...

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Main Authors: Gangjee, Aleem, Zaware, Nilesh, Raghavan, Sudhir, Disch, Bryan C., Thorpe, Jessica E., Bastian, Anja, Ihnat, Michael A
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602277/
https://ncbi.nlm.nih.gov/pubmed/23434139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.01.040
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