Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

Novel small molecule antagonists of NPBWR1 (GPR7) are herein reported. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 5-chloro-4-(4-methoxyphenoxy)-2-(p-tolyl)pyridazin-3(2H)-one as a NPBWR1 hit antagonist with micromolar activity. Design, s...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Urbano, Mariangela, Guerrero, Miguel, Zhao, Jian, Velaparthi, Subash, Saldanha, S. Adrian, Chase, Peter, Wang, Zhiwei, Civelli, Olivier, Hodder, Peter, Schaeffer, Marie-Therese, Brown, Steven, Rosen, Hugh, Roberts, Edward
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601546/
https://ncbi.nlm.nih.gov/pubmed/23079522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.09.074
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados