Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

Novel small molecule antagonists of NPBWR1 (GPR7) are herein reported. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 5-chloro-4-(4-methoxyphenoxy)-2-(p-tolyl)pyridazin-3(2H)-one as a NPBWR1 hit antagonist with micromolar activity. Design, s...

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Detaylı Bibliyografya
Asıl Yazarlar: Urbano, Mariangela, Guerrero, Miguel, Zhao, Jian, Velaparthi, Subash, Saldanha, S. Adrian, Chase, Peter, Wang, Zhiwei, Civelli, Olivier, Hodder, Peter, Schaeffer, Marie-Therese, Brown, Steven, Rosen, Hugh, Roberts, Edward
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601546/
https://ncbi.nlm.nih.gov/pubmed/23079522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.09.074
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