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SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists
In this Letter we report on the advances in our NPBWR1 antagonist program aimed at optimizing the 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy)pyridazin-3(2H)-one lead molecule previously obtained from a high-throughput screening (HTS)-derived hit. Synthesis and structure–activity relationshi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3621982/ https://ncbi.nlm.nih.gov/pubmed/23287738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.12.030 |
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