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DNA Damage Regulates UHRF1 Stability via the SCF(β-TrCP) E3 Ligase
UHRF1 (ubiquitin-like, with PHD and RING finger domains 1) is a critical epigenetic player involved in the maintenance of DNA methylation patterns during DNA replication. Dysregulation of the UHRF1 level is implicated in cancer onset, metastasis, and tumor recurrence. Previous studies demonstrated t...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3592027/ https://ncbi.nlm.nih.gov/pubmed/23297342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01191-12 |
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