SCFβ‐TrCP ubiquitinates CHK1 in an AMPK‐dependent manner in response to glucose deprivation

The ATR/CHK1 pathway is a key effector of cellular response to DNA damage and therefore is a critical regulator of genomic stability. While the ATR/CHK1 pathway is often inactivated by mutations, CHK1 itself is rarely mutated in human cancers. Thus, cellular levels of CHK1 likely play a key role in...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Ma, Ying, Cui, Danrui, Xiong, Xiufang, Inuzuka, Hiroyuki, Wei, Wenyi, Sun, Yi, North, Brian J., Zhao, Yongchao
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360357/
https://ncbi.nlm.nih.gov/pubmed/30428154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12403
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