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Targeted polyubiquitylation of RASSF1C by the Mule and SCF(β-TrCP) ligases in response to DNA damage
RASSF1A [Ras association (RalGDS/AF-6) domain family member 1A] and RASSF1C are two ubiquitously expressed isoforms of the RASSF1 gene. The promoter of RASSF1A is frequently hypermethylated, resulting in inactivation in various human cancers. RASSF1A is implicated in the regulation of apoptosis, mic...
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| Udgivet i: | Biochem J |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4610364/ https://ncbi.nlm.nih.gov/pubmed/21910689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111500 |
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