The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCF(β-TrCP) E3 Ligase

The TAZ transcription co-activator promotes cell proliferation and epithelial-mesenchymal transition. TAZ is inhibited by the Hippo tumor suppressor pathway, which promotes TAZ cytoplasmic localization by phosphorylation. We report here that TAZ protein stability is controlled by a phosphodegron rec...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Chen-Ying, Zha, Zheng-Yu, Zhou, Xin, Zhang, Heng, Huang, Wei, Zhao, Di, Li, Tingting, Chan, Siew Wee, Lim, Chun Jye, Hong, Wanjin, Zhao, Shimin, Xiong, Yue, Lei, Qun-Ying, Guan, Kun-Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988322/
https://ncbi.nlm.nih.gov/pubmed/20858893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.152942
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