Optimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice

Some of the main concerns with in vivo application of naked small interfering RNA are rapid degradation and urinary excretion resulting in a short plasma half-life. In this study we investigated how conjugation of polyethylene glycol (PEG) with variable chain length affects siRNA pharmacokinetics an...

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Bibliografski detalji
Glavni autori: Iversen, Frank, Yang, Chuanxu, Dagnæs-Hansen, Frederik, Schaffert, David H., Kjems, Jørgen, Gao, Shan
Format: Artigo
Jezik:Inglês
Izdano: Ivyspring International Publisher 2013
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590589/
https://ncbi.nlm.nih.gov/pubmed/23471415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.5743
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