Optimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice

Some of the main concerns with in vivo application of naked small interfering RNA are rapid degradation and urinary excretion resulting in a short plasma half-life. In this study we investigated how conjugation of polyethylene glycol (PEG) with variable chain length affects siRNA pharmacokinetics an...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Iversen, Frank, Yang, Chuanxu, Dagnæs-Hansen, Frederik, Schaffert, David H., Kjems, Jørgen, Gao, Shan
Formato: Artigo
Idioma:Inglês
Publicado: Ivyspring International Publisher 2013
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590589/
https://ncbi.nlm.nih.gov/pubmed/23471415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.5743
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares