The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice

Instability and inadequate biodistribution of double-stranded RNA are major drawbacks to the clinical use of RNA interference. This work compares chemical modification and nanoparticle formulation as strategies to improve the systemic delivery of small interfering RNA (siRNA). Variable levels of che...

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Autori principali: Gao, Shan, Dagnaes-Hansen, Frederik, Nielsen, Ebbe Juel Bech, Wengel, Jesper, Besenbacher, Flemming, Howard, Kenneth Alan, Kjems, Jørgen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835214/
https://ncbi.nlm.nih.gov/pubmed/19401674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.91
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