The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice

Instability and inadequate biodistribution of double-stranded RNA are major drawbacks to the clinical use of RNA interference. This work compares chemical modification and nanoparticle formulation as strategies to improve the systemic delivery of small interfering RNA (siRNA). Variable levels of che...

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Detalhes bibliográficos
Main Authors: Gao, Shan, Dagnaes-Hansen, Frederik, Nielsen, Ebbe Juel Bech, Wengel, Jesper, Besenbacher, Flemming, Howard, Kenneth Alan, Kjems, Jørgen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835214/
https://ncbi.nlm.nih.gov/pubmed/19401674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.91
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