Lipidoid-siRNA Nanoparticle-Mediated IL-1β Gene Silencing for Systemic Arthritis Therapy in a Mouse Model

Interleukin-1 beta (IL-1β) plays a central role in the induction of rheumatoid arthritis (RA). In the present study, we demonstrated that lipidoid-polymer hybrid nanoparticle (FS14-NP) can efficiently deliver siRNA against IL-1β (siIL-1β) to macrophages and effectively suppress the pathogenesis of e...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Song, Ping, Yang, Chuanxu, Thomsen, Jesper Skovhus, Dagnæs-Hansen, Frederik, Jakobsen, Maria, Brüel, Annemarie, Deleuran, Bent, Kjems, Jørgen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697342/
https://ncbi.nlm.nih.gov/pubmed/31153827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.05.002
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