Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles

Harnessing the RNA interference pathway offers a new therapeutic modality; however, solutions to overcome biological barriers to small interfering RNA (siRNA) delivery are required for clinical translation. This work demonstrates, by direct northern and quantitative PCR (qPCR) detection, stability,...

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Bibliographische Detailangaben
Hauptverfasser: Ballarín-González, Borja, Dagnaes-Hansen, Frederik, Fenton, Robert A, Gao, Shan, Hein, San, Dong, Mingdong, Kjems, Jørgen, Howard, Kenneth A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098703/
https://ncbi.nlm.nih.gov/pubmed/23462963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.2
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