A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

Small interfering RNAs (siRNAs) are now established as the preferred tool to inhibit gene function in mammalian cells yet trigger unintended gene silencing due to their inherent miRNA-like behavior. Such off-target effects are primarily mediated by the sequence-specific interaction between the siRNA...

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Main Authors: Bramsen, Jesper B., Pakula, Malgorzata M., Hansen, Thomas B., Bus, Claus, Langkjær, Niels, Odadzic, Dalibor, Smicius, Romualdas, Wengel, Suzy L., Chattopadhyaya, Jyoti, Engels, Joachim W., Herdewijn, Piet, Wengel, Jesper, Kjems, Jørgen
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943616/
https://ncbi.nlm.nih.gov/pubmed/20453030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq341
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