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A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects
Small interfering RNAs (siRNAs) are now established as the preferred tool to inhibit gene function in mammalian cells yet trigger unintended gene silencing due to their inherent miRNA-like behavior. Such off-target effects are primarily mediated by the sequence-specific interaction between the siRNA...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943616/ https://ncbi.nlm.nih.gov/pubmed/20453030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq341 |
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