In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts

The clinical use of small interfering RNA (siRNA) is hampered by poor uptake by tissues and instability in circulation. In addition, off-target effects pose a significant additional problem for therapeutic use of siRNA. Chemical modifications of siRNA have been reported to increase stability and red...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Mook, ORF, Vreijling, Jeroen, Wengel, Suzy L, Wengel, Jesper, Zhou, Chuanzheng, Chattopadhyaya, Jyoti, Baas, Frank, Fluiter, Kees
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109444/
https://ncbi.nlm.nih.gov/pubmed/21687525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/adna.1.1.12204
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados