In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts

The clinical use of small interfering RNA (siRNA) is hampered by poor uptake by tissues and instability in circulation. In addition, off-target effects pose a significant additional problem for therapeutic use of siRNA. Chemical modifications of siRNA have been reported to increase stability and red...

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Bibliographic Details
Main Authors: Mook, ORF, Vreijling, Jeroen, Wengel, Suzy L, Wengel, Jesper, Zhou, Chuanzheng, Chattopadhyaya, Jyoti, Baas, Frank, Fluiter, Kees
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2010
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109444/
https://ncbi.nlm.nih.gov/pubmed/21687525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/adna.1.1.12204
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