Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

Therapeutic application of the recently discovered small interfering RNA (siRNA) gene silencing phenomenon will be dependent on improvements in molecule bio-stability, specificity and delivery. To address these issues, we have systematically modified siRNA with the synthetic RNA-like high affinity n...

Full description

Saved in:
Bibliographic Details
Main Authors: Elmén, Joacim, Thonberg, Håkan, Ljungberg, Karl, Frieden, Miriam, Westergaard, Majken, Xu, Yunhe, Wahren, Britta, Liang, Zicai, Ørum, Henrik, Koch, Troels, Wahlestedt, Claes
Format: Artigo
Language:Inglês
Published: Oxford University Press 2005
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC546170/
https://ncbi.nlm.nih.gov/pubmed/15653644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki193
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items