Locked nucleic acid containing antisense oligonucleotides enhance inhibition of HIV‐1 genome dimerization and inhibit virus replication

We have evaluated antisense design and efficacy of locked nucleic acid (LNA) and DNA oligonucleotide (ON) mix‐mers targeting the conserved HIV‐1 dimerization initiation site (DIS). LNA is a high affinity nucleotide analog, nuclease resistant and elicits minimal toxicity. We show that inclusion of LN...

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Bibliografiske detaljer
Udgivet i:FEBS Lett
Main Authors: Elmén, Joacim, Zhang, Hong-Yan, Zuber, Bartek, Ljungberg, Karl, Wahren, Britta, Wahlestedt, Claes, Liang, Zicai
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2004
Fag:
Short Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7232750/
https://ncbi.nlm.nih.gov/pubmed/15589834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2004.11.015
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