Locked nucleic acid containing antisense oligonucleotides enhance inhibition of HIV‐1 genome dimerization and inhibit virus replication

We have evaluated antisense design and efficacy of locked nucleic acid (LNA) and DNA oligonucleotide (ON) mix‐mers targeting the conserved HIV‐1 dimerization initiation site (DIS). LNA is a high affinity nucleotide analog, nuclease resistant and elicits minimal toxicity. We show that inclusion of LN...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:FEBS Lett
Main Authors: Elmén, Joacim, Zhang, Hong-Yan, Zuber, Bartek, Ljungberg, Karl, Wahren, Britta, Wahlestedt, Claes, Liang, Zicai
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2004
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7232750/
https://ncbi.nlm.nih.gov/pubmed/15589834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2004.11.015
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados