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Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
Therapeutic application of the recently discovered small interfering RNA (siRNA) gene silencing phenomenon will be dependent on improvements in molecule bio-stability, specificity and delivery. To address these issues, we have systematically modified siRNA with the synthetic RNA-like high affinity n...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC546170/ https://ncbi.nlm.nih.gov/pubmed/15653644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki193 |
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