A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo

BACKGROUND: The proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important factor in the etiology of familial hypercholesterolemia (FH) and is also an attractive therapeutic target to reduce low density lipoprotein (LDL) cholesterol. PCSK9 accelerates the degradation of hepatic low densit...

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書誌詳細
主要な著者: Gupta, Nidhi, Fisker, Niels, Asselin, Marie-Claude, Lindholm, Marie, Rosenbohm, Christoph, Ørum, Henrik, Elmén, Joacim, Seidah, Nabil G., Straarup, Ellen Marie
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2010
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871785/
https://ncbi.nlm.nih.gov/pubmed/20498851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010682
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