Expanding the design horizon of antisense oligonucleotides with alpha-l-LNA

Oligonucleotides containing Locked Nucleic Acids (LNA) to various extents and at various positions were evaluated for antisense activity, RNase H recruitment, nuclease stability and thermal affinity. In this work, two different diastereoisomers of LNA were studied: the beta-d-LNA and the alpha-l-LNA...

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Hlavní autoři: Frieden, Miriam, Christensen, Signe M., Mikkelsen, Nikolaj D., Rosenbohm, Christoph, Thrue, Charlotte A., Westergaard, Majken, Hansen, Henrik F., Ørum, Henrik, Koch, Troels
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2003
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC275462/
https://ncbi.nlm.nih.gov/pubmed/14576324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg820
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