Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

The potency and specificity of locked nucleic acid (LNA) antisense oligonucleotides was investigated as a function of length and affinity. The oligonucleotides were designed to target apolipoprotein B (apoB) and were investigated both in vitro and in vivo. The high affinity of LNA enabled the design...

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Bibliographic Details
Main Authors: Straarup, Ellen Marie, Fisker, Niels, Hedtjärn, Maj, Lindholm, Marie W., Rosenbohm, Christoph, Aarup, Vibeke, Hansen, Henrik Frydenlund, Ørum, Henrik, Hansen, Jens B. Rode, Koch, Troels
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978335/
https://ncbi.nlm.nih.gov/pubmed/20615897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq457
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