Optimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice

Some of the main concerns with in vivo application of naked small interfering RNA are rapid degradation and urinary excretion resulting in a short plasma half-life. In this study we investigated how conjugation of polyethylene glycol (PEG) with variable chain length affects siRNA pharmacokinetics an...

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Autores principales: Iversen, Frank, Yang, Chuanxu, Dagnæs-Hansen, Frederik, Schaffert, David H., Kjems, Jørgen, Gao, Shan
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2013
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590589/
https://ncbi.nlm.nih.gov/pubmed/23471415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.5743
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