Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury

Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial-mediated neurodegeneration in vitro, and is neuroprotective in experimental models of CNS injury. In vitro studies als...

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Главные авторы: Loane, David J., Stoica, Bogdan A., Byrnes, Kimberly R., Jeong, William, Faden, Alan I.
Формат: Artigo
Язык:Inglês
Опубликовано: Mary Ann Liebert, Inc. 2013
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589874/
https://ncbi.nlm.nih.gov/pubmed/23199080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2012.2589
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