Enhanced Akt/GSK-3β/CREB signaling mediates the anti-inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

We have previously shown that treatment with a mGluR5 positive allosteric modulator (PAM) is neuroprotective after experimental traumatic brain injury (TBI), limiting post-traumatic neuroinflammation by reducing pro-inflammatory microglial activation and promoting anti-inflammatory and neuroprotecti...

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Detalhes bibliográficos
Publicado no:J Neurochem
Main Authors: Bhat, Shahnawaz, Henry, Rebecca J., Blanchard, Alexa C., Stoica, Bogdan A., Loane, David J., Faden, Alan I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386074/
https://ncbi.nlm.nih.gov/pubmed/31926033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14954
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