Neutral Sphingomyelinase Inhibition Alleviates LPS-Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury

Neuroinflammation is one of the key secondary injury mechanisms triggered by traumatic brain injury (TBI). Microglial activation, a hallmark of brain neuroinflammation, plays a critical role in regulating immune responses after TBI and contributes to progressive neurodegeneration and neurologic defi...

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Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Kumar, Asit, Henry, Rebecca J., Stoica, Bogdan A., Loane, David J., Abulwerdi, Gelareh, Bhat, Shahnawaz A., Faden, Alan I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2019
Schlagworte:
Neuropharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367691/
https://ncbi.nlm.nih.gov/pubmed/30563941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.253955
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