Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury

Traumatic brain injury (TBI) causes microglial activation and related neurotoxicity that contributes to chronic neurodegeneration and loss of neurological function. Selective activation of metabotropic glutamate receptor 5 (mGluR5) by the orthosteric agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHP...

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Detaylı Bibliyografya
Yayımlandı:Neurotherapeutics
Asıl Yazarlar: Loane, David J., Stoica, Bogdan A., Tchantchou, Flaubert, Kumar, Alok, Barrett, James P., Akintola, Titilola, Xue, Fengtian, Conn, P. Jeffrey, Faden, Alan I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer US 2014
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391388/
https://ncbi.nlm.nih.gov/pubmed/25096154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-014-0298-6
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