Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury

Traumatic brain injury (TBI) causes microglial activation and related neurotoxicity that contributes to chronic neurodegeneration and loss of neurological function. Selective activation of metabotropic glutamate receptor 5 (mGluR5) by the orthosteric agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHP...

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Bibliografiske detaljer
Udgivet i:Neurotherapeutics
Main Authors: Loane, David J., Stoica, Bogdan A., Tchantchou, Flaubert, Kumar, Alok, Barrett, James P., Akintola, Titilola, Xue, Fengtian, Conn, P. Jeffrey, Faden, Alan I.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391388/
https://ncbi.nlm.nih.gov/pubmed/25096154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-014-0298-6
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