Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury

Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial-mediated neurodegeneration in vitro, and is neuroprotective in experimental models of CNS injury. In vitro studies als...

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Autors principals: Loane, David J., Stoica, Bogdan A., Byrnes, Kimberly R., Jeong, William, Faden, Alan I.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2013
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589874/
https://ncbi.nlm.nih.gov/pubmed/23199080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2012.2589
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