p-(4-Azipentyl)-propofol: A Potent Photoreactive General Anesthetic Derivative of Propofol

We synthesized 2,6-Diisopropyl-4-[3-(3-methyl-3H-diazirin-3-yl)-propyl]-phenol (p-(4-azipentyl)-propofol), or p-4-AziC5-Pro, a novel photoactivable derivative of the general anesthetic propofol. p-4-AziC5-Pro has an anesthetic potency similar to propofol. Like propofol, the compound potentiates inhi...

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Main Authors: Stewart, Deirdre S., Savechenkov, Pavel Y., Dostalova, Zuzana, Chiara, David C., Ge, Rile, Raines, Douglas E., Cohne, Jonathan B., Forman, Stuart A., Bruzik, Karol S., Miller, Keith W.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580944/
https://ncbi.nlm.nih.gov/pubmed/22029276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200943f
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