Загрузка...

Synthesis and Biological Evaluation of a New Series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as Human A(2A) Adenosine Receptor Antagonists with Improved Water Solubility

The structure activity relationship (SAR) of 1,2,4-triazolo[1,5-a]-1,3,5-triazine derivatives related to ZM241385 as antagonists of the A(2A) adenosine receptor (AR) was explored through the synthesis of analogues substituted at the 5 position. The A(2A) AR X-ray structure was used to propose a stru...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Federico, Stephanie, Paoletta, Silvia, Cheong, Siew Lee, Pastorin, Giorgia, Cacciari, Barbara, Stragliotto, Stefano, Klotz, Karl Norbert, Siegel, Jeffrey, Gao, Zhan-Guo, Jacobson, Kenneth A., Moro, Stefano, Spalluto, Giampiero
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578427/
https://ncbi.nlm.nih.gov/pubmed/21214204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101349u
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!