Synthesis and Biological Evaluation of a New Series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as Human A(2A) Adenosine Receptor Antagonists with Improved Water Solubility

The structure activity relationship (SAR) of 1,2,4-triazolo[1,5-a]-1,3,5-triazine derivatives related to ZM241385 as antagonists of the A(2A) adenosine receptor (AR) was explored through the synthesis of analogues substituted at the 5 position. The A(2A) AR X-ray structure was used to propose a stru...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Federico, Stephanie, Paoletta, Silvia, Cheong, Siew Lee, Pastorin, Giorgia, Cacciari, Barbara, Stragliotto, Stefano, Klotz, Karl Norbert, Siegel, Jeffrey, Gao, Zhan-Guo, Jacobson, Kenneth A., Moro, Stefano, Spalluto, Giampiero
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578427/
https://ncbi.nlm.nih.gov/pubmed/21214204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101349u
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados