The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives

A new series of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine (PTP) derivatives has been developed in order to explore their affinity and selectivity profile at the four adenosine receptor subtypes. In particular, the PTP scaffold was conjugated at the C2 position with the 1-(3-trifluoromethyl-ben...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Federico, Stephanie, Redenti, Sara, Sturlese, Mattia, Ciancetta, Antonella, Kachler, Sonja, Klotz, Karl-Norbert, Cacciari, Barbara, Moro, Stefano, Spalluto, Giampiero
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666649/
https://ncbi.nlm.nih.gov/pubmed/26625265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143504
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